Effect of propofol, thiopentone and etomidate on adrenal steroidogenesis in vitro.
نویسندگان
چکیده
The i.v. anaesthetic agents propofol, thiopentone and etomidate inhibited ACTH-stimulated production of cortisol by guineapig dispersed adrenal cells in a dose-related manner. For two of the drugs, propofol and thiopentone, inhibition occurred over a similar concentration range: 2 X 10(-5) - 5 X 10(-4) mol litre-1. With etomidate, inhibition occurred over a much lower concentration range (5 X 10(-8) - 5 X 10(-6) mol litre-1). The concentrations of anaesthetic which induced 50% inhibition of cortisol secretion were propofol 1.7 X 10(-4), thiopentone 1.6 X 10(-4), and etomidate 1.0 X 10(-7) mol litre-1.
منابع مشابه
Parke-Davis Medicated Throat Discs: chloroforming that throat "tickle".
37. Davies B, Morris T: Physiological parameters in laboratory animals and humans. Pharm Res 1993; 10:1093–5 38. Fraser R, Watt i, gray Ce, ledingham iM, lever AF: the effect of etomidate on adrenocortical function in dogs before and during hemorrhagic shock. endocrinology 1984; 115:2266–70 39. Kruse-elliott Kt, swanson CR, Aucoin DP: effects of etomidate on adrenocortical function in canine su...
متن کاملEffect of thiopentone, etomidate and propofol on systemic vascular resistance during cardiopulmonary bypass.
We have studied the effect of thiopentone, etomidate and propofol on systemic vascular resistance (SVR) during cardiopulmonary bypass with constant pump flow in 30 patients undergoing elective coronary artery bypass surgery. SVR decreased to 78% of control values after thiopentone 4 mg kg-1, to 72% of control after etomidate 0.3 mg kg-1, and to 68% of control after propofol 2 mg kg-1; it return...
متن کاملEffectiveness of sodium thiopentone, propofol, and etomidate as an ideal intravenous anesthetic agent for modified electroconvulsive therapy
INTRODUCTION Electroconvulsive therapy (ECT) is a well-established psychiatric treatment in which seizures are electrically induced in patients for therapeutic effects. ECT can produce severe disturbances in the cardiovascular system and a marked increase in cerebral blood flow and intracranial pressure. These cardiovascular changes may be altered using various anesthetic drugs. AIM AND OBJEC...
متن کاملComparison of the Haemodynamic Effects of Three Different Methods at the Induction of Anaesthesia.
OBJECTIVE Haemodynamic variations are inevitable during induction of anaesthetic drugs. The present study investigates the haemodynamic variations of three different drugs (thiopental, propofol, and etomidate) used for induction of general anaesthesia together with fentanyl. METHODS In a randomized, double-blind study, 45 patients were assigned to one of three groups (n=15 each). Fentanyl 1 μ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- British journal of anaesthesia
دوره 57 5 شماره
صفحات -
تاریخ انتشار 1985